With this resounding win, England clinched the series 2-0, with one match remaining.
Tammy Beaumont was the star of the show, scoring a brilliant 150 from 139 balls, her 10th ODI century, to help England post a commanding total of 320 for 8. Beaumont's knock, laced with 16 fours and one six, saw her surpass Nat Sciver-Brunt to become England's leading centurion in women's ODIs.
Freya Kemp added a quickfire 65 from 47 balls, forming a century partnership with Beaumont for the fourth wicket.
Ireland's chase never gained momentum, with the hosts bundled out for just 45 in 16.5 overs. England's stand-in captain Kate Cross set the tone early, taking 3 for 8, including two wickets in the first over. Lauren Filer followed with 3 for 10, while Freya Kemp (2 for 7) and Georgia Davis (2 for 19) wrapped up the innings. Ireland's Una Raymond-Hoey was the only batter to reach double figures, scoring 22.